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Of Observe is the fact, due to PEA’s significant lipophilicity, micronized or extremely-micronized formulations are thought to become more quickly absorbable, with more favorable pharmacokinetics and better efficacy. Despite the fact that there is some proof supporting this principle, there is still no evidence of the superiority of micronized PE
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2016a). This smaller sized boost was proportionate to the scaled-down peak of PEA concentrations detected in human volunteers in contrast with beagle canines. This distinction, in turn, is usually a result of the reduce total volume of PEA acutely administered to human volunteers (about ∼five vs. 30 mg·kg−one in puppies) and to the fact that